Antigenotoxic effect of lupeol isolated from sesbaniagr and ifloraleaves using cancer induced mouse model
Abstract
Sesbaniagrandiflora leaves were collected from maruthuvalmalai in kanyakumari district (Tamil Nadu, India) and identified by a plant taxonomist. Isolation of chemical components of methanol extract was done. The isolated compounds were identified as lupeol (C30H50O), kemferol (C15H10O6) and gallic acid (C7H6O5). The compound Lupeol is subjected to Genotoxicity and Comet assay. In the present study the therapeutic potential of lupeol was evaluated in cancer induced mouse model. The results reveal that cancerous changes induced was suppressed by lupeol.